Objectives of present study was to evaluate the anti–inflammatory activity of Withania Somnifera in experimentally induced inflammation in albino rats.Inflammation was inducedby non–immunological and Immunological methods and measured by standard methods. For each set of experiment,animals were divided in five groups of six animals each. 1stgroup was given normal saline, 2nd group standard anti–inflammatory drug and 3rd, 4&5th groups were given Withania Somniferain doses of 400, 800 & 1600mg/kg respectively. In present study it is found thatWithania Somniferashow significant anti–inflammatory activity. So Withania Somniferaexhibited significant and promising anti–inflammatoryactivity in all the experimental models.