Introduction: World–over, tuberculosis (TB) remains as a major public health issue, mostly affecting the lesser privileged. TB involving the central nervous system (CNS) contributes to less than 1% of infections caused by it. Early recognition of CNS TB with early treatment is of paramount importance to optimum outcome. Objectives: The objectives were to study the clinical profile of patients with central nervous system tuberculosis and to study the socio–demographic and clinical risk factors that predispose to its development. It was a retrospective descriptive chart–based study on 30 Patients of CNS TB admitted between 1^st January 2016 to 31^st December 2017. Results: Among the 30 patients included, there were 22 males and 8 females. Fever, headache and vomiting were the most common presenting features. The median time of presentation was 3 days. Neck stiffness and Kernig’s test were the most common signs. CSF analysis showed lymphocyte predominance, with low glucose; elevated protein and ADA levels. Leptomeningeal enhancement and vasculitic infarcts were common neuroimaging features. The mean duration of stay was 15.23 days. Partial recovery was noted in 22 and death in 2 out in this study. Conclusion: CNS TB can occur in all ages with a male preponderance continues to pose challenges, both in diagnosis and management, with significant morbidity and mortality.