Human beings are much concerned about the direct effect of pollutants on their own health. Arsenic being a potent environmental toxic agent, leads to development of various hazardous effects on human health. Elevated concentrations of inorganic arsenic, a potent toxicant and carcinogen in drinking water are common worldwide.A large number of reports show associations between arsenic exposure and multiple noncancer health effects, e.g., diabetes, skin diseases, chronic cough, and toxic effects on liver, kidney, cardiovascular system, peripheral and central nervous systems.It has been reported that there are increased incidences of arsenic toxicity even at low and permissible dose limit. The present review discusses some of the health issues related with arsenic toxicity.