Thyroid nodule or swelling also called as goiter can be easily diagnosed clinically. Many tests and procedures are available for evaluation of the thyroid nodules. Among them FNAC is the initial investigation in euthyroid nodules. AIMS: To observe the correlation of FNAC and Histopathology in various thyroid disorders, To stress the importance of HPE as final diagnostic tooland The role of surgery as diagnostic and therapeutic method .METHODS AND MATERIALS: This study includes about 100 patients who were operated for solitary and multinodular thyroid disease, suspicious malignant disease and malignant disease.RESULTS &CONCLUSION: In our study the commonest thyroid disease affecting the study population are solitary nodular goiter, multi nodular goiter, hashimoto’s, papillary carcinoma of thyroid.This study concludes nodular colloid goiter is the commonest benign lesion and papillary carcinoma is the commonest malignant lesion.The incidence of malignancy in multi nodular goiter 10.9%.The incidence of carcinoma in solitary nodular goiter is 22.2%.FNAC is simple, safe and cost effective but HPE remains final diagnostic tool, because FNAC cannot differentiate between adenoma and carcinoma in follicular and hurthle cell lesions.