Cholecystectomy is commonly performed operation in a surgical settingfor symptomatic cholelithiasis. We aimed to conduct histological evaluation for all such cases at institutional level. The objectives were to confirm the clinico–radiological diagnosis, identification of unsuspected findings including incidental gallbladder malignancy, audit, research & quality control. Currently, there is a developing trend to consider selective histological evaluation of surgical specimen.This article discusses the need for histopathological evaluation of gallbladder specimens following cholecystectomy specimens removed routinely.  The changing age of the population and the increasing incidence of cholelithiasis make it likely that the incidence of carcinoma of the gallbladder will also increase. In India, the incidence of gall bladder malignancy is variable in different geographicalareas. Cholecystectomy for benign gallbladder diseases can lead to detection of previously undiagnosed gallbladder cancer during histopathological evaluation. Despite some controversy over its usefulness, histopathological evaluation of all gallbladder specimens is common in most hospitals.