IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-7-8-16355 Original Research Paper FORMULATION OF POROUS BASED OSMOTIC DRUG DELIVERY SYSTEM OF METOPROLOL SUCCINATE Dr. August 2018 7 8 01 02 ABSTRACT

Controlled release dosage forms cover a wide range of prolonged action formulations which provide continuous release of their active ingredients at a pre determined rate and for a predetermined time. The majority of controlled release formulation are designed for oral administration. The objective of the present study is to design Controlled Porous Osmotic Pump Tablet (CPOPT) of Metoprolol Succinate. It was observed that predominantly the drug was released through the pores at a constant rate. The drug is freely soluble in water and administered at a dose of 47.5 mg daily. Half life of Metoprolol Succinate is 3–4 hrs. Hence, an attempt is made to formulate a Porous Osmotic Pump to regulate the release of Metoprolol Succinate by using CPOP system to reduce dosing frequency, avoid dose dumping and maintain uniform plasma concentration of drug and improve the patient compliance. The present study aimed to develop a porous osmotic drug delivery system for controlled release of highly water soluble drug MetoprololSuccinate .core tablet of Metoprolol Succinate containing the mixture of osmogens i.e., Lactose and Fructose with different ratios were formulated and coated with Cellulose Acetate to form nonporous coating membrane. Further 0.4 mm delivery orifices were drilled on one side of the tablet, to select best formulation for further characterization. The present study to analyze the feasibility to consider metoprolol succinate in the form of porous osmotic drug delivery system and sustained release, clearly confirmed that this type of formulation can be administered safely for the treatment of anti–hypertension with improved therapeutic efficacy.Osmotically controlled oral delivery system can be used as once–a day controlled release formulation,thus improved patient compliance.