Background. Renal cell carcinoma have specific histopathological ,genetic characteristics  &Prognostic markers such as tumor grade, and necrosis or microvascular invasion are useful for determining appropriate follow–up and selecting patients for adjuvant therapy. Hence, the objective of the current study was to evaluate these pathological variables and histopathological spectrum of RCC .Material and Methods. –107 cases of radical nephrectomy received in Pathology Department ,Madras Medical College, were included in this retrospective study. Age, sex, histologic subtype,  Fuhrman grade(except for chromophobercc,primary squamous cell carcinoma , ewings sarcoma and adult wilms) tumor necrosis and microvascular invasion were determined in all cases. Results. Clear cell, papillary, chromophobecarcinomas ,sarcomatoid, adult Wilms ,primary squamous cell carcinoma and ewingssarcoma.accounted for 85 (79%), 8(8%), 5(4.6%), 5(4.6%), adult wilms 2(1.8%), 1(0.93%) and 1(0.93%) cases, respectively. Fuhrman grade 2 and pT3 stage were predominant features, tumor necrosis was identified in one third of investigated tumors and microvascular invasion in 9 tumors (8.4%).
Conclusions: Most tumors were clear cell type and had a predilection for G2 and pT3 categories, instead papillary form, the second as frequency, had higher values regarding grading and tumor necrosis, but lower stage. Tumor necrosis correlates with higher grade and tumor stage.