Dengue virus infection is a major and important public health problem in many South East Asian countries and also in more than 100 countries of tropical and subtropical region.¹Two–fifths of the world’s population or 2500 million people are now at risk for dengue, and every year approximately 50 million new cases occur world wide²Dengue is the most common arboviral disease transmitted globally, is caused by four antigenically distinct dengue virus serotypes (DEN 1, DEN 2, DEN 3 and DEN 4).The global prevalence of dengue infection has increased dramatically in the recent decades.Dengue infection of classical type has been endemic in India for many years. Recently an increasing trend of outbreaks of dengue infections and its severe forms have been reported in India.Factors responsible for dengue’s spread include explosive population growth, unplanned urban overpopulation with inadequate public health systems, poor vector control and increased international travel to endemic areas. Indeed Dengue without or with warning signs is a fast emerging global health problem.Dengue viral infections are known to present a diverse clinical spectrum, ranging from asymptomatic illness to severe dengue. Unusual manifestations of dengue infections such as encephalitis, GullianBarre syndrome, hemolytic uremic syndrome, dengue hepatitis, myocarditis, acute respiratory distress syndrome are recognized and they have become more common in recent years.