IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-7-8-16473 Original Research Paper BCG VACCINE LOCAL CUTANEOUS ADVERSE EFFECTS AND CLINICAL COMPLICATIONS: A HOSPITAL RESEARCH SHAM PRASAD Dr. August 2018 7 8 01 02 ABSTRACT

Twenty patients were diagnosed as having localcutaneouscomplications. Abscess formation (30%), localized inflammationsigns (45%), purulent discharge (10%), crust (10%) and eczematouslesion (5%) were found as local cutaneous complications. Drainagewas performed in 14 (70%) patients. Oral amoxicillin clavunate therapywas given to four (20%) patients due to isolating Staphylococcusaureus(2/4), Staphylococcus hominis(1/4), and Exiguobacteriumaurantiacum(1/4) from the drainage or purulent discharge culture.Anti–tuberculosis drugs (isoniazid and rifampicin) were used in six(30%) patients. Five of them had positive acid–resistant bacilli, tuberculosispolymerase chain reaction or tuberculosis culture results andone (5%) patient was diagnosed as having a lupus vulgaris becausehistopathological examination of his lesion showed granulomatousdermatitis. In addition, there was no lesion to drain in four (20%)patients and they were followed without treatment. On follow–up, alllesions completely recovered.There is no still consensus about treatment of the localcomplication after BCG vaccine. In our study, some complications improved with conservative treatment. However, drainage, anti–tuberculosisdrugs and antibiotic treatments were needed in some cases.As a result, treatment should be decided to each patient’s clinicalsymptoms and underlying disease.BacilleCalmette–Guerin (BCG) vaccine may causesome cutaneous complications at the injection site. Although someof these are normal reactions, unexpected complications may be seen.Clinical features, treatment modalities and outcomes of these complicationshave notbeen clearly defined in literature. We aimed todetermine the local cutaneous complications after BCG vaccine andclinical experiences in our hospital.Between May 2014 and December 2017, previouslyhealthy children aged older than 2 months, without underlying diseaseor drug use history, who were admitted with localized cutaneouscomplications after BCG vaccine, were retrospectively analyzed. Demographicand clinical features, laboratory findings, treatments and

outcomes were collected from database.