An in vitro study was conducted to compare microleakage in nanohybrid composite restorations in Class V cavities using total etch and self–etch adhesives and two different horizontal layering techniques. Cavitieswere made on buccal and lingual surfacesof forty extracted premolar teeth and divided into groups A and B containingbuccal surface cavities treated with total etch adhesive system andlingual surface cavities treated with Single step adhesive respectively. Cavities were restored using nanohybrid composite and randomly divided into four subgroupsdepending on incremental technique used. Specimens were then immersed in methylene blue dye for 24 hoursand analysed under stereomicroscope for dye penetration. Results indicated microleakage with all groups with total etch group showing superior results than self etch group and group in which occlusal increment was placed first showing superior results than group with gingival increment placed first.