Typhoid fever, a common infectious disease may present with  only  a febrile illness or with various life threatening  intestinal as well as  extraintestinal complications.  Resistance to multiple antibiotics including 3^rd generation cephalosporins  is emerging and posing serious health problems.
We report a case of Typhoid fever who presented with high grade fever, thrombocytopenia, hepatitis, myocarditis and milliary nodules in the lung.  Salmonella Typhi  isolated from bone marrow showed resistance to multiple drugs.