Mesodiverticular band (believed to be remnant of a vitelline artery) causing gangrene of Meckel’s diverticulum (MD) with simultaneous mechanical small bowel obstruction is the rarest complication of Meckel’s Diverticulum. We report a case of 34 year female, who presented with acute small bowel obstruction caused by Mesodiverticular band of MD. She presented with severe abdominal pain, distension and vomiting. Laparotomy revealed gangrene of Meckel’s diverticulum along with adjacent ileal segment caused by a Mesodiverticular band of MD. The mesodiverticular band was released from the ileal mesentery and the gangrenous ileal segment with MD was resected and an end to end ileoileal anastomosis was performed. The postoperative period was uneventful and the patient was discharged after 6 days. Because of the rarity of this anatomic anomaly in adults, we find this case of interest.