Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the brain and spinal cord, commonly affecting young adults & occurs most frequently between ages 25 – 35 years, the cause remains unknown to modern medicine. Theories include genetics, infections, and environmental factors. Inflammation in nervous system is hallmark of MS, inflammation occurs in spots that are scattered in brain and spinal cord and they are called plaques. The body’s own immune system attacks and damages the myelin. Immune reactions turn on/activate lymphocytes, these eat holes through the lining of venules and enter nervous system and initiate inflammation in CNS leading to demylination. The present report deals with a case of Multiple sclerosis diagnosed under the preview of majjakshaya and praanaavrutavyanaaccording to Ayurveda. Efficacy of treatment was calculated by using Modified Ashworth scale for muscle tone, Barthel index of activities for daily living and Berg balance scale for balancing. Before treatment, total score of Modified Ashworth scale was 4, Barthel index of activities of daily living was 17 and Berg balance scale score was 47, after treatment the scores were 2, 18 and 49 respectively. Good improvement was observed in walking, reduction in pain and moderate improvement was seen in weakness of the extremities. Ayurveda panchakarma therapies along with internal medications have provided promising results in the present case.