Background:Deficiencies influence clinical interpretations of parathyroid hormone.This study analysed gender differences in parathyroid hormone and related analytes after excluding deficiencies in healthy young adults.

Methods:Healthy participants aged 18 to 25 years from near sea level Kerala, who wereevaluated clinically and by quantitative biochemical analytes to exclude common diseases, but include deficiencies of analytes related toparathyroid hormone, took part in this observational cross sectional study.

Results:Before exclusion of deficiencies, gender differences were seen in analytes related to parathyroid andcorrelations of parathyroid hormone were difficult to interpret.After exclusion of deficiencies,gender differences were lost in all analytes except hemoglobin. Correlations of parathyroid hormonewere negative with hemoglobin, but positivewith erythropoietin in females and negative with iron in males. Androgens increase hemoglobin causing loss of correlation of parathyroid hormone with erythropoietin.

Conclusion:Exclusion of deficiencies in analytes related to parathyroid hormone brought out differences in regulation of hemoglobin in healthy males and females.