Hand, foot, and mouth disease (HFMD) is a syndrome, caused by Coxsackie virus, characterized by fever with vesicular eruptions principally on the skin of the hands and feet and the oral cavity. HFMD primarily affects infants and young children. Although infection is usually self–limited, severe neurological complications in the central nervous system can present in some cases, which can lead to death. Most Coxsackie virus infections are mild and self–limiting. The patient may be manifested with the common cold, sore throat and distinctive rashes on the palms, soles, inside the oral cavity, tongue, gums and cheek, known as a hand–foot–mouth disease (HFMD), more frequent in children under 5–10 years. The diagnosis of Coxsackie virus infection is typically clinical. Usually, no treatment is required for mild infection because of the ability of the body immune system to destroy the viruses. Patient with severe signs and symptoms treatment is supportive. Hand hygiene, Environmental hygiene and creating public awareness are the key steps for the prevention and control of this viral infection.