Chronic Fatigue Syndrome is one of those clinical presentations which is most often misdiagnosed to be various other conditions. After the recent news featured in ‘The Nature” on the reboot of chronic fatigue syndrome in January 2018, this paper is a trial to provide deeper insight into CFS (Chronic Fatigue Syndrome) and the possibilities of managing the condition with alternative systems of medicine especially Homoeopathy to improve the quality of life of the patients suffering with this illness through a retrospective observational pilot study.