AIM :To know the association between hormone receptorstatus and pathological response in carcinoma breastafter neo adjuvant chemotheraphy.

Methods: Pts with LABC(Locally advanced breast cancer) stageII and stage III treated with PC(Primary  Chemotherapy) including A( anthracycline) and T(taxane) were grouped according to ER(estrogen receptor), PR(progesterone receptor) and HER2 status, and the pCR(pathological complete response) rate were analyzed using the chi–squared test and correlations with a p value of ≤0.05 were considered statistically significant.

Conclusion: We conclude that  neoadjuvant chemotheraphy is recommended for patients with hormone receptor negative status , which gives pCR . Thereby enhances patients OS(overall)& DFS(disease free survival).