This study was to find out Correlation of Plasma D–Dimer levels in Breast Cancer Patients with Clinical Stage, Lymph Node Metastasis and Hormone receptor status. 36 breast patients of breast neoplasm according to selection criteria were included in this study which after triple assessment were evaluated for D–Dimer status. In this study of 36 patients of breast neoplasm, statistically significant association was found between plasma D–Dimer levels and clinical stage of breast cancer(p value=.0025). Proportion of plasma D–Dimer positive cases with higher stage of tumor was more compared to plasma D–Dimer negative cases.No significant association was observed between plasma D–Dimer levels and mean age of patients, pathology of the tumor Lymph node metastasis, hormone receptor status and Her–2/neu receptor over expression.