BACKGROUND &AIMS: Helicobacter pylori is the most common chronic bacterial infection in the world with prevalence varying  worldwide . To compare the eradication rates of H.pylori between treatment with 2weeks Clarithromycin based triple drug regimen & 6weeks dual drug regimen containing Amoxicillin &Omeprazole in patients with gastric or duodenal ulcer disease.

PATIENTS &METHODS: Prospective randomized controlled study.Totalsample size 197 .One arm receives triple drug regimen  for 2 weeks. Second arm receives   dual drug regimen for 6weeks.

RESULTS:Total 197 patients were included in the study of which 98 patients received  triple drug regimen & 99 patients received dual drug regimen .H.pylori eradication rate between the triple drug regimen & dual drug regimen is statistically significant with p value 0.0142.

CONCLUSION:H.pylori eradication rate with dual drug regimen for 6 weeks is inferior to Clarithromycin based triple drug regimen for two weeks.