Introduction :Bacteremia caused by staphylococcus aureus continues to be a common problem worldwide. In the pre–antibiotic era, most cases occurred in young patients without underlying disease. The associated death rate was 82%¹ .even with antimicrobial drug treatment.Staphylococcus aureus is present in the nose (usually temporarily) of about 30% of healthy adults and on the skin of about 20%. The percentages are higher for people who are patients in a hospital or who work there.

Materials and Methods : A hospital based prospective study where total of 100 blood samples of patients that were received at microbiological laboratory are included by random sampling. T.he clinical profile of MRSA have been studied .

Results : Of the 100 samples , 38 blood samples turned to be positive for MRSA with the common comorbidity associated was diabetes mellitus and most of the cases were from the post–operative wards. The common complication was sepsis. Among the tested groups of antibiotics, MRSA was maximally sensitive to 3^rd generation cephalosporins(47.3%).

Conclusion : The most common hospital acquired infection especially in the post operative wards is staphylococcus aureus. So adequate precautions should be necessarily be taken to prevent cross infection among patients against this dreaded organism.The geographical pattern of sensitivity to various antibiotics will help us to initiate treatment empirically when suspected before the blood culture reports and available.