BACKGROUND: The main objective of this study was to determine the prevalence of pseudomonas aeruginosa’s in the surgical site infection patient and its susceptibility to commonly used antibiotics.

MATERIALS AND METHOD: During a period of 1 year, specimens were collected as the postoperative wound swabs in the microbiology department, owaisi hospital and research centre, Hyderabad, India.

RESULT: Out of 100 samples collected, 30 samples were of p.aeruginosa, followed by 20 samples of E.coli, klebsiella sps 17 samples, staphylococcus aureus 14 samples,proteus sps 6 samples, acinetobacter 3 samples, citrobacter freundii 1 sample, there was no growth in 9 specimens.

CONCLUSION:p.aeruginosa isolation was higher in male patients, in the age group of 21–40 years. The susceptibility pattern showed the organism to be most commonly susceptible to imipenem, meropenem, cefoperazone/sulbactam, ticarcillin/clavulanate, and amikacin.