BackgroundAnalgesic drugs used to alleviate pain are laden with adverse effects.Mentha piperita is a herbaceous plant used in traditional medicine.The leaves contain ethereal oil, tannins, flavonoids and they possess diverse medicinal properties.Aim and Objective:To evaluate the analgesic effect of aqueous extract of leaves of Mentha piperita in adult swiss male albino mice in comparison with aspirin.Materials and Methods:Analgesic effect was evaluated using Eddy’s hot plate method and tail–clip method in 30 inbred male albino mice procured from central animal house, Madurai Medical college and divided into five groups, with six rats in each group. Group I served as control .Group II received T.Aspirin– 100 mg/kg (oral). Group III,IV and V  received graded doses of 200,400 ,600 mg /kg of aqueous extract of  Mentha piperita (oral). Results:Mentha piperita at all 3 doses had significant dose dependant analgesic activity when compared to the control groupand  the  600 mg/kg dose  had analgesic activity comparable to that of aspirin. Conclusion: The aqueous extract of leaves of Mentha piperita at the dose of 600 mg/kg had analgesic activity comparable to that of aspirin. The analgesic effects may be mediated both centrally and peripherally.