Background:To study the seroprevalence of transfusion–transmissible Infections(TTI’s) among Blood Donors in Southern India.

Methods:The present retrospective study was carried out at blood bank in Anam Chenna Subba Reddy (ACSR) Government General Hospital,Nellore,Andhra Pradesh.Data regarding age,sex,residence of donors and screening test results were collected from the records of blood bank over a period of 5 years(January 2013 to December 2017.

Results: A total of 11,234  blood donors were screened during the study period, of which 10,949 (97.5%) were males and  285 (2.5%) were females. The overall seroprevalence of TTI were 2.5% among these HIV, HBV and HCV were 0.3%, 1.8% and 0.1% respectively; for syphilis, the seroprevalence was estimated to be 0.1%.

Conclusion: Prevention of  TTI’s  can be achieved by stringent  screening  of donors and donated bloods