Background: Limiting blood loss presents a challenge to the surgeon. An external, hemostatic agent – Feracrylum can be a good companion in major head and neck surgeries.

Methods: Total Sample size was 30 patients undergoing major head and neck surgery. These patients were randomly assigned to either group A (Feracrylum group, n = 15) or group B (normal saline group, n = 15).

Results: The mean difference in Haemoglobin values of group A and B were compared and greater drop were seen in group B as compared to group A on postoperative day 2 and 5 (p = 0.229), and more number of patients had greater loss (>2gm %) in group B. The mean values of drain collection were always more in group B when compared to group A

Conclusion: It was observed in this study that 1% Feracrylum solution led to decrease in blood loss from surgical wounds, though the results were not statistically significant. It was found to be safe with no adverse effects on hepatic or renal parameters.