ABSTRACT

IJSR

International Journal of Scientific Research

2277 - 8179

Indian Society for Health and Advanced Research

ijsr-7-10-16882

Original Research Paper

A STUDY ON THE USEFULLNESS OF ACTIVATED LYMPHOCYTES AND LYMPHOCYTE COUNT IN PREDICTING EPSTEIN–BARR VIRUS INFECTIOUS MONONUCLEOSIS.

Dr. DR.T.M.KARTHIKESHWARAN

Dr.

October 2018

7 10 01 02 ABSTRACT

INTRODUCTION: Infectious mononucleosis (IM) is caused by Epstein–Barr virus(EBV) commonly among adolescents and children presenting

with fever, malaise, sore throat, palatal petechiae, enlarged tonsils, cervical lymphadenopathy, lymphocytosis with atypical lymphocytes in blood,

hepatosplenomegaly, jaundice and rarely splenic rupture. The present study analysed the predictive diagnostic accuracy of total leucocyte count,

absolute lymphocyte count and percentage of atypical lymphocytes in the blood to diagnose IM

AIMS AND OBJETIVES:

Ÿ To evaluate the clinical usefulness and predictive value of blood parameters– lymphocytosis and presence of atypical lymphocytes in

diagnosing Infectious mononucleosis.

METHODOLOGY: This study was conducted among 898 patients with serological report for EBV, blood count reports, and with clinical signs &

symptoms suggestive of Infectious Mononucleosis over a 5 year period from January 2014 to August 2018.

CONCLUSION: Evaluation of blood parameters namely lymphocytosis, atypical lymphocytes, and WBC to lymphocyte ratio could significantly

help in the diagnosis of Infectious mononucleosis but cannot replace serology.