Laryngoscopy and intubation often leads to haemodynamic changes which is detrimental with certain subset of patients.Aim of the study : To compare the effect of intravenous dexmedetomidine, lignocaine and fentanyl for obtundation of the pressor response.Material and methods:  Seventy eight patients were randomised into three groups to receive intravenous Dexmedetomidine (Group–D) , Lignocaine (Group–L) and Fentanyl (group–F) before intubation.  After routine protocol of induction and intubation, haemodynamic parameters were noted during different time points after intubation .The requirement for propofol for induction was also noted. Data was analyzed using Student’s t–test and Fisher’s exact test.  Results: Overall there was no significant haemodynamic changes in all the three groups except the SBP, DBP, MAP decreased significantly at 5 and 10 mins of intubation than baseline. (p<0.05) . Propofol requirement in group D was significantly less than the other groups.(p=0.01).Conclusion: The effect of dexmedetomidine , lignocaine and fentanyl were comparable for attenuation of  pressor response, while the induction agent requirementwas less in dexmedetomidine group.