Background: Thyroid diseases with accompanying dyslipidemia is widely recognized as a risk factor for various cardiovascular disease like atherosclerosis/myocardial infarction,which cannot be fully explained by the atherogenic lipid profile and plasma total homocysteine is an independent risk factor forthe initiation of atherosclerosis. OBJECTIVE: The aim of this study was to investigate the serum total homocysteine level in subclinical as well as overt hypothyroid patients of North/West Indians to observe the relationship between lipid, homocysteine and hypothyroidism. MATERIAL AND METHODS:  In the present study, 80 hypothyroid patients (40 sub clinical hypothyroidism and 40 overt hypothyroidism) and 40 normal healthy controls  subjects of both sex, with a mean age range 20–50 years from North West Punjabi population were recruited in the present study for the evaluation of serum total homocysteinealong with lipid and lipoproteins levels. RESULTS:In the present a significant increase in total cholesterol (P ≤ 0.05), triglycerides (P ≤ 0.001), LDL– cholesterol (P ≤ 0.05),  and VLDL–cholesterol was observed in sub clinical and overt hypothyroid patientswhile a significant fall (P ≤ 0.001) in both sub clinical hypothyroidism and overt  hypothyroidism was reported in comparison to normal healthy subjects.A significant (P ≤ 0.001) increase in total homocysteine level was recorded in overt hypothyroidism but non significantly increased was observed in total homocysteine levels in sub clinical hypothyroidismpatients.Conclusion: A strong relationship between serum homocysteine levels and lipid profile concentrations especially the concentrations of total cholesterol and triglycerides in hypothyroidism might increase cardiovascular risk. So, determination of serum levels of thyroid profile is recommended in subjects with unexplained Hyperhomocysteinemia.