Background: A brain tumor is an intracranial solid neoplasm which involves varied types of cells. Management strategies and prognosis of tumor depends on the combination of factors like the type and grade of tumor, its location, size and state of development. So definite typing of brain tumor by histological examination is essential for appropriate treatment. Methods: This retrospective study was carried out from August 2017 to July 2018 in RIMS Ranchi. A total of 55 brain tissue biopsy samples were collected irrespective of age and sex along with patients’ clinical diagnoses, CT scan or MRI report, and operative findings and histological diagnosis were done. Results: Majority (38.18%) of the study subjects belonged to 41–50 years of age group with male predominance (63.64%). Astrocytoma comprised the largest group (38.18%). Conclusions: It is concluded from this study that among the different varieties of brain lesions astrocytoma is the most common with male predominance between the age group of 40–49 years confirmed by biopsy and histopathology along with CT or MRI.