Background: Urinary bladder lesions, non–neoplastic and neoplastic, are jointly accountable for substantial morbidity and mortality throughout the world.

Objective:Aim of the present study was to analyse the histopathological features of various lesions in bladder biopsies and to study the frequency of different pathological lesions at a tertiary care institute.

Materials and methods:This was a prospective study done over a period of two year in the Department of Pathology, MMIMSR, Mullana from 1st April 2016 to 31th March 2018. Histopathological examination of specimens was carried out and the lesions were classified into various types on light microscopy.

Results: A total of 96 urinary bladder biopsies were studied in a period 2 years. Age of the patients in our study ranged from 21 years to 89 years with a peak age incidence of cases in 7th decade. Among the 96 cases, 7 were non– neoplastic and 89 were neoplastic lesions. Amongst the 89 neoplastic lesions maximum cases were of urothelial neoplasms.

Conclusion: The present study was undertaken mainly to highlight the importance of histopathological examination in the diagnosis of bladder lesions.