Amoebiasis is a parasitic infection caused by Entamoeba histolytica occurring in populations with low socio–economic status and is transmitted by faeco–oral route. It mainly involves the intestine and liver and presents as acute abdomen and loose stools. A 73   years old female presented with pain in abdomen and loose stools since 2 days. Radiological investigations revealed inflammation of the appendix and thickening of the colonic wall and clinical presentation prompted emergency surgical intervention with a suspicion of Crohn’s disease clinically and a postoperative diagnosis of amoebic colitis was made on histopathology.