Introduction: This study was conducted for analysing multidrug resistant, extensive drug resistant and pan drug resistant strains of Klebsiella pneumoniae and its antimicrobial susceptibility pattern from critical areas of a tertiary care centre.

Methods: Analysis of multi drug resistant Klebsiella pneumoniae was carried out using WHONET software. Data included all the clinical specimen tested in Microbiology laboratory for aerobic culture and susceptibility by Kirby Bauer‘s disc diffusion method and  MIC method as per availability. The results were interpreted by CLSI guidelines 2016 – 2017

Results: Multi drug resistant Klebsiella strains from Critical areas of the hospital were 98 %, Extensive drug resistant strains were 57 % and Pan drug resistant strains were 9 %.

Conclusions: Continuous monitoring of  multi drug resistant, extensive drug resistant and pan drug resistant Klebsiella pneumoniae among other orgasnisms, should be done in intensive care units to form a rational antibiotic policy for better infection control management of severely ill patients.