Aim and Objectives: To study the clinical profile, identify predisposing factors, management and complications in patients presenting primarily with Deep Vein Thrombosis (DVT).  Method: This study was done on 75 cases of Duplex Venous Ultrasound (DVU) proven DVT over a 2–year period. Clinical and ultrasonographic outcome of DVT after 1 week, 2 weeks and 3 months were recorded. Results: Younger age groups (30–39 years) were affected more commonly (28%). Majority of cases (39) had coexistent involvement of both proximal and distal veins. Swelling and pain of affected extremity were the most common clinical presentation. The majority of patients had no obvious predisposing factors. Around 60% of cases have complete clinical resolution and approximately 50% cases have complete ultrasonographic resolution at the end of 3 months. Conclusion:  The patients in younger age groups and without  any obvious risk factors often present primarily with DVT.  Hence, we recommend testing and assessment for genetic and acquired causes of thrombosis in these patients. Early initiation and adequate anticoagulation will reduce chronic complications.