Background: Extensive warts is a challenging condition to treat. Vitamin D3 is a new modality which acts by enhancing cell‑mediated immunity against the warts. Aim: To evaluate the efficacy and safety of Intralesional vitamin D3  in extensive and recalcitrant warts. Methods: 50 patients with multiple warts of varying sizes and duration were included in the study. 0.2– to 0.5–mL vitamin D3 solution (600,000 IU, 15 mg/mL) was injected at the base of the wart. A maximum of 5 warts were injected per session at 3–week intervals until resolution or for a maximum of 4 treatments. Patients were followed up for 6 months to detect any recurrence. Results: Complete response was seen in 38/50 (76%), partial response in 7/50 (14%) and no response in 5/50 (10%). Average sittings required to achieve complete resolution was 3.46. Side effects like erythema, edema, pain and induration were seen in 12% which were either self limiting or managed with analgesics. Recurrence was seen in 6%. Limitations: There was no control group in our study. Conclusion: Intralesional vitamin D3 is effective, safer and an inexpensive treatment option for extensive and recalcitrant warts