BACKGROUND: Despite being a rare tumor, Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. A series of patients presenting with GIST at our college was studied and correlated with previously published data.

SETTINGS AND DESIGN: The study was conducted in Surgical Oncology Department, SAIMS, Indore. This was an observational study.

Materials and Methods: We reviewed the clinical presentation, imaging features, operative findings and histopathological & immunohistochemistry findings in 12 patients with GIST from 2015 to 2017. Patients were followed for 6 months to two years.

RESULTS:

Total 12 patients were studied. Mean age 49.75 years (range 35– 70 years).

Most common location was in stomach (50 %),25% in ileum, 16 % in jejunum and rectum was least common seen in 9% case. All except one had a R0 resection. IHC showed cKIT and DOG1 positivity in all cases. Two patients had metastatic lesion. There was single 28–day mortality. All patients received post–operative Imatinib.

CONCLUSION: GISTs being rare tumor should be reported for appropriate consensus. Improved histopathological and immunohistochemistry techniques have helped to confirm the diagnosis.

Surgery and medical therapy with imatinib and other TKIs is the cornerstone of treatment.