Cryptogenic Cirrhosis remains a human clinical condition although recent advances  allow for a better understanding of underlying conditions associations.
 Typical patient are middle age with only minor liver enzymes abnormalities. Presentations range from incidentally discovered cirrhosis to complications of advanced portal HTN and hepatocellular cancer Clinico–pathological analysis of this patient indicates that the leading causes include previously unrecognized non Alcoholic–steatohepatitis (NASH), silent auto immune hepatitis , non– B,  non–C viral hepatitis and occult past ethanol  exposure.