IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-7-11-17202 Original Research Paper STUDY OF THE ROLE OF FROZEN SECTION EVALUATION IN PATIENTS WITH BREAST LESIONS Prasad Dr. Dr Brajendra Kumar Dr. November 2018 7 11 01 02 ABSTRACT

 Frozen section is an invaluable intra–operative tool for evaluation of breast lumps.The aim of this study was to calculate the overall accuracy, false positivity, false negativity for frozen section of breast lumps,to analyze the causes of discrepancies, and  compare the data with that of published literature on frozen section of breast lumps.300 frozen sections comprising 286 breast lumps, 10 axillary nodes and 4 lumpectomy margins received for frozen section were analyzed. Pathology reports and slides (of both frozen and paraffin sections) were reviewed. The values were calculated using paraffin slides as the gold standard.The 286 lumps received for primary diagnosis comprised 206 malignant and 80 benign lesions. The  false negativity rate was 0.42%, false positive rate 0%, deferral rate 0.84%, overall accuracy rate was 99.57%. The false negative diagnosis was an error of interpretation. False negativity rate for axillary nodes was 20% and accuracy was 80%. Accuracy for margins was 100%.Frozen section  has a role despite the raging popularity of aspiration cytology in the following settings: (1) Difficult cytology (2) Evaluation of lumpectomy margins. (3) Intra–operative nodal status