The aim of this study is to establish and compare the antidiabetic effect of ethanolic extract of Cynodon Dactylon (in Streptozotocin Induced diabetic albino rats) with that of glimepiride  and  metformin. For this purpose, rats were subjected to induce diabetes by intraperitoneal injection of a single dose of 50 mg/kg body weight of streptozotocin. Rats with serum glucose levels > 200 mg /dl were subdivided into four sub–groups; the first sub–group were remained without treatment and considered as diabetics. The second third and fourth subgroups were orally administered 500 mg/kgbody wt. ethanolic extract of cynodon dactylon, 0.03mg (1.5ml) glimepride and 9mg (0.9ml) metformin respectively for a period of 28 days. Although, ethanolic extract of cynodon dactylon has good effect in lowering of fasting blood sugar in diabetic rats but this effect only become significant after 14 days and have slower onset of action and take more time to achieve euglycemic level of FBS in comparison to Glimepiride and Metformin