Background: The head and neck cancers is  the  sixth  cancer by incidence worldwide.^[1] Few studies showed that reduced E–cadherin expression and positive vimentin expression is associated with decrease in differentiation and stage disease and hence poor prognosis of the patient. ^[2,3] METHODS: Sixty newly diagnosed  HNSCC cases were included. H&E staining and immunohistochemistry for E–cadherin and Vimentin was performed. RESULTS: Most common site was oral cavity 71.6%. Out of 60 cases 67% cases showed reduced E–cadherin expression (p=0.013),  58% cases showed positive vimentin expression at ITF (p=0.245). Reduced E–cadherin and positive vimentin expression at ITF seen more in TNM  stage  I and II and also seen more in well differentiated tumor  (p<0.001). CONCLUSION:  Most common site involved was oral cavity and significant correlation was found between reduced E–cadherin expression, but no significant correlation was found with positive vimentin expression at ITF.