Aim: The aim of our study was to estimate Liver enzymes and to establish GGT as a sensitive indicator of hepatobiliary diseases.

Study design: A hospital based cross sectional study was conducted on patients attending the Outpatient Department of Medicine of SMIH for a period of 06 months from June 2017 to December 2017. 112 clinically confirmed liver disease cases and 80 age and sex matched controls in the group 20–80 years were included in the study. Exclusion criteria was age less than 20 years & more than 80 years.

Methodology: 5ml of venous blood was collected from both cases & controls and analyzed for Liver Function–Total Serum Bilirubin, SGOT, SGPT, ALP, GGT and Total Protein on a fully automated analyzer 5600 of OCD.

Results: We found a significant increase in the values of Total Serum Bilirubin, Serum Transaminases and Serum ALP, Serum GGT when compared with normal controls in both males & females.