Randomized blind study was carried out in 60 patients aged 18–65 ASA grade I & II, scheduled for elective  Laparoscopic surgeries under general anaesthesia.

Patients were randomly allotted in 2 groups comprising 30 patients each. Group A: received Ondansetron (0.1 mg/kg)

Group B: received Palonosetron (0.075 mg)

After arrival to the operation theatre baseline monitoring– pulse blood pressure, ECG, SPO₂ observed & recorded. Intravenous line was secured. All patients were premedicated. Then Ondansetron or Palonosetron were given according to the group selection. After pre–oxygenation, induction with inj Thiopentone 5–7 mg/kg & facilitating intubation inj Succinylcholine 2 mg/kg were given. Patients were intubated and maintained with O₂ & Sevoflurane and muscle relaxant.

Vital parameters like pulse, BP, SPO₂, ECG, ETCO₂ were monitored throughout the surgery.After adequate oropharyngeal and endotracheal suctioning patients were extubated. Patients were shifted to post anaesthesia care unit for further follow up & observation. In post operative period, patients were monitored for vitals, episodes of vomiting, severity of nausea, complete response, requirement of rescue antiemetic, adverse drug reaction during 0–6, 6–24 & 24–72 hrs duration.