Introduction: A seizure or convulsion is a paroxysmal, time–limited change in motor activity and/or behaviour that results from abnormal electrical activity in the brain. Neonatal seizures are abnormal electrical discharges in the central nervous System of neonates usually manifesting as a stereotyped muscular activity or autonomic changes.

Aims and Objectives: To  Study Etiology, Onset and Type of Neonatal Seizures 

Methodology:  The present study included 107 neonates presenting with seizures admitted to the NICU of MGM Medical College & Hospital, Aurangabad, during the period of two years from 1st  June 2013 to 31st May 2015. All participants in the study were subjected to all investigations mentioned in the proforma, except for neuroimaging which was an optional investigation. The data were analyzed using software like Epi–info, Microsoft Excel.

Result: Chi–squared for the onset of seizures on the first three days and more than three days with aetiology, χ2 =13.1312 with a p–value of 0.0107. Seizures during the first three days of life have a statistically significant correlation with birth asphyxia with a P value of < 0.05. Out of 71 neonates with birth asphyxia, 36 (50.7%) had subtle seizures, followed by GTS in 26 neonates (36.62%) & MFC in 6 (8.45%) neonates. In neonates with hypoglycemic seizures, 7 out of 15 (46.67%) babies had subtle seizures followed by GTS in 6 (40%), neonates. In neonates with meningitis (10 neonates), 5 developed subtle seizures (50%) and 3 had MFC (30%). In our study, there was no correlation between the type of neonatal seizures with the aetiology (p>0.05).

Conclusion:  The recognition of the aetiology of neonatal seizures is often helpful with respect to prognosis and treatment.