Ankylosing spondylitis is a chronic inflammatory disease primarily affecting the spine and sacroiliac joint. Many patients are suffering from this disease from a long time but do not find any authentic treatment. This case illustrates the potential of ayurvedic medications and panchkarma therapies in the management of ankylosing spondylitis. A 48 year old man consulted in OPD of CBPACS, with complaints of gradually progressive lowerback pain alongwith stiffness in neck, unable to move neck and rolling himself on the bed & prediagnosed case of ankylosing spondylitis. Treatment was done with ayurvedic medications and panchkarma procedures in two phases. In 1^st phase Abhyang, Patrapindpottalisvedana and Nadisvedan for 15 days, in 2^nd phase Greevabasti, Patrapindpottalisvedana and Sarvang Vashpasveda were given for 18 days. According to BASFI patient got 30% functional improvement and 16.66% anatomical improvement after first phase and 45% functional improvement and 38.88 % anatomical improvement after second phase treatment