INTRODUCTION: This study is done to analyse the traditional teacher–centred/ subject–based teaching and learning approach & student–centred teaching and learning approach. And also to study and analyse the lecture teaching and learning method and problem based teaching and learning method besides large group teaching and learning method and small group teaching and learning method.

MATERIAL AND METHODS: This was a descriptive cross–sectional study. 100 students out of 150 M.B.B.S. students of second professional in Department of Pharmacology, T.S.M. Medical College, were randomly selected for this study. Data collection tools included a 6–items questionnaire. The questions were 5 pointed ranging from extremely appropriate/possible to not appropriate/possible.

RESULTS: The results showed that the students preferred the teacher–centred teaching and learning approach (67%), lecture teaching and learning method (75%). Our results further revealed that small group teaching and learning method was extremely possible for discussion (85%), clarification of doubts (86%) and interaction with teacher (94%).

CONCLUSION: The students of T.S.M. Medical College, Lucknow more preferred teacher–centred approach, lecture method and small group method. The teacher must have an exceptional personality who inspires students and allows the students to think, discuss, ask questions for clarification of doubts and interact with him.