Isaac’s  syndrome  or  Neuromyotonia  is a disorder characterized by continuous muscle fiber activity with peripheral nerve hyperexcitability and typical electromyography features . The acquired form occur with autoimmune diseases, paraneoplastic syndromes and toxins. We describe 4 patients in whom Neuromyotonia was diagnosed after consumption of ayurvedic  medications and was confirmed by presenting symptoms, physical examination , electrophysiologic findings  and auto–antibody  results. There could be suboptimal or undetectable levels of heavy metals/ elements triggering autoimmunity  in these ayurvedic preparations. They expose VGKC channels on nerve endings leading to prolonged repolarization and Neuromyotonia. Immediate identification and withdrawl of drug is needed for amelioration of symptoms with prompt immunosuppressive therapy