Introduction: Pyogenic infections are a common presentation in a hospital. Emerging antimicrobial resistance is posing a threat to current treatment protocols. This study was conducted to determine bacteriological and antibiotic susceptibilityprofile of the isolates from pus samples.

Materials and methods: 316 pus samples were received from November 2016 to April 2017. Samples were processed as per standard microbiological methods and antibiotic susceptibility tested using Kirby– Bauer test.

Result: Staphylococcus aureus(26.7%)was the most frequent pathogen followed by Escherichia coli (20.7%), Pseudomonas aeruginosa (17.3%),Klebsiella spp (14.7%). 42% of S.aureus isolates were Methicillin Resistant. Ertapenem was uniformly effective for all the E coli isolates.

Conclusion:In view of high prevalence of MRSA , strict implementation of infection control measures is needed. Susceptibility data is worrisome with resistance to frequently used drugs. Continuous surveillance is required to look for trends in data to formulate institutional guidelines.