Aim– Primary aim of our study is to establish and analyse the relationship between serum CA125 levels and response of epithelial ovarian cancer to treatment.

Patients and method– 46 patients of ovarian cancer of variable age group received treatment at our centre. Patients were then kept on follow–up and at each follow–up serum CA–125 was measured to observe the disease response. Later on level of serum CA–125 was then correlated with recurrence, residual or metastatic disease.

Results– Of 46 patients diagnosed with ovarian cancer serum CA–125 level was recorded in all the patients before treatment and on completion of first–line therapy at each follow–up. Serum CA 125 levels were found to be raised in all the patients before starting treatment. While during treatment and during post treatment follow–ups mean CA 125 level remained decreasing