Background: Novel approaches are required to counter the threat of emerging multidrug resistance Gram negative bacteria (GNB) in clinical settings. Efflux pump inhibitors to overcome drug resistance have been a field of interest for past two decades. In this study we explored the efficacy of recently launched neoadjuvant antibiotic entity, “elores” comprising of ceftriaxone, sulbactam and EDTA, against multidrug resistant Gram negative bacteria.

Materials and methods: A total of 150 multidrug resistant GNBs were isolated from various clinical samples were included in study. All the isolates except P.aeruginosa and Burkholderia cepacia were tested for susceptibility against elores.

Results: Out of 136 MDR GNBs tested, 76 (55.88%) were sensitive to elores. Maximum sensitivity was observed for E.coli (72.97%) followed by Klebsiella pneumonia (48.33%), Acinetobacter baumanii (57.14%).

Conclusion: The results shows that significant number of  MDR GNB were susceptible to elores and its inclusion in treatment of these infections should be considered.