Recurrent Feotal loss (RFL) is a serious and potentially devastating health problem. An interest in autoimmune causes of RFL has greatly increased with the discovery of an association between presence of APA and ANA. Study was conducted to check association of significant autoantibodies in RFL in Nair Hospital, Mumbai comprising of 143 women in study group having history of RFL and 140 women in control group, clinically normal with no history of RFL. Anticardiolipin antibodies (ACA) (IgG and IgM) and total Antinuclear Antibodies (ANA) (IgG and IgM combined) and Lupus Anticoagulant (LA) giving prolonged “Activated Partial Thromboplastin Time” tests were carried out  by the kits. Incidence of autoantibody was not found in control group. Highest % of autoantibodies was ACA (31.47%) followed by LA (19.35%) and ANA (15.22%) in the study group. However, none of these associations of APA and ANA in RFL were statistically significant. All these women were treated with low dose aspirin. There was no treatment offered to women who possessed LA and ANA. Out of 45(31.46%) sero–positive women for ACA, only 23 (51.11%) complied with the treatment while 22 (48.88%) did not comply with the treatment. Comparison between these two groups for their foetal outcome was found to be statistically not significant. Many issues about APS still remain poorly understood. To develop guidance on the best treatment options, well–designed randomized trials are required.