Introduction: Creating personalized learning environments with the set of tools and spaces defined by the user in order to make the best of the learner’s educational experience is the ulterior motive of 21^st century educators. The content delivery, implemented by adjunctive tools, enables the learner to engage in an asynchronous manner i.e., where the traditional boundaries in a learning environment are erased. The aim of the article is to consider the utility of these two applications over the full scope of anatomy education and generating best practices for supplementing education.

Methods:   The scope, entire gamut and the technical utilities of the two commonly used note taking applications namely Microsoft OneNote® AND EverNote ®are described in all possible parameters.

Results: The advantages, disadvantages, features comparison and requirements for endeavouring optimal personalized learning environment are described along with the learning outcomes of the personalized learning applications.

Discussion and conclusion: The versatility and complexity offered by these personalized learning apps possibly increase the degrees of freedom available for the learner. The appropriate utility of the abovementioned apps would promote self–regulated learning and reduced barriers to the pursuit of internally motivated learning. This would also suffice the essential components of self–regulated learning such as self–monitoring and evaluation.