INTRODUCTION – Observing the low incidence of infections following laparoscopic cholecystectomy, the need for antibiotics is frequently being questioned. The overuse of antibiotics can result in rising frequency of adverse effects, emergence of drug resistant organisms.

METHODS – In study group, no antibiotic was given at the time of induction of anaesthesia whereas in control group, one dose of injection Ceftriaxone 1 g IV was given at the time of induction of anaesthesia. A sample of bile will be aspirated with the needle from gall bladder and sent to microbiological laboratory for bacterial detection. The postoperative course will be monitored for incidents such as fever, infection at trocar site.

RESULTS – The p–values drawn for the difference in the number of patients in either group having positive bile culture, postoperative fever, signs of inflammation and wound discharge came out to be less than 0.05. The p–values drawn for the difference in the number of patients having post op surgical site infection in relation to report of bile culture and intra op bile or stone spillage came out to be less than 0.05.

CONCLUSION – Intraoperative bile and gall stone spillage has poor correlation with the postoperative surgical site infections. Statistically insignificant differences are there between the two study groups as far as postoperative surgical site infections are concerned.